Methods, systems, devices and computer program product include: (i)
administering a fluorescent analyte to a subject; (ii) repetitively
emitting excitation light from an implanted sensor over a desired
monitoring period; (iii) detecting fluorescence intensity in response to
the excitation light using the implanted sensor that outputs the
excitation light; and (iv) using data associated with the detected
fluorescence intensity to perform at least one of: (a) calculate the
concentration or dose of the analyte received proximate to the implanted
sensor site; (b) evaluate the pharmacodynamic or pharmacokinetic activity
of the fluorescent analyte; (c) confirm Ab attachment to a tumor site;
(d) monitor a non-target site to confirm it is not unduly affected by a
therapy; (e) monitor for changes in cellular properties; (f) use the
calculated dose or concentration data to adjust or customize a
therapeutic amount of the analyte administered to the subject; (g)
confirm micelle concentration at a target site and then stimulate toxin
release based on the confirmation; and (h) monitor for the expression of
a protein produced from a gene therapy modification.In particular
embodiments, the intensity of the excitation signals emitted to the
localized tissue can be varied in a predetermined manner to generate
optical profiling data of the response of the tissue proximate the
sensor.