System and method for creating a graphical program that uses multiple models of computation (MoC). A first plurality of graphical program elements is assembled in a graphical program in response to first input, where the assembled first plurality of graphical program elements have a first MoC. A structure is displayed in the graphical program indicating use of a second MoC for graphical program elements comprised within the interior of the structure. A second plurality of graphical program elements is assembled within the structure in response to second input, where the assembled second plurality of graphical program elements have the second MoC. The graphical program is executable to perform a function, for example, by executing the assembled first plurality of graphical program elements in accordance with the first model of computation, and executing the assembled second plurality of graphical program elements in accordance with the second model of computation.