The invention relates to an adjusting and guiding system for guiding tools (1) in relation to a workpiece (2), said system comprising the following characteristics: a navigation system (3) used to identify reference points, a first reference point unit (4) that can be fixed to the workpiece (2), a first template receiving element (5) that can be fixed to the workpiece (2), a second reference point unit (6) that can be fixed to the first template receiving element (5), and a template. Said template comprises a coupling part (7a) adapted to the first template receiving element, a tool guiding element (7b) adapted to the tool (2) to be guided, a lockable coupling device (7c) connecting the coupling part (7a) to the tool guiding element (7b) and enabling the tool guiding element (7b) to be oriented in relation to the coupling piece (7a), and a template adjusting device (8). Said template adjusting device is characterised by a second template receiving element (8a) connected to the template adjustment device (8) in a geometric relation therewith, the first and the second template receiving elements being identical, a tool guiding coupling (8b) for the defined connection of the tool guiding element (7b) of the template to the template adjustment device (8), and an adjusting device (8c) comprising adjusting elements that can be displaced in a defined manner and are used for the defined orientation of the tool guiding coupling (8b), said adjusting elements (8c) being provided with measuring scales.