Extracts of various species of the Moraceae family have estrogenic properties. For example, aqueous and ethanolic extracts of Scuttelaria barbata D. Don of the Labiatae Family species possess estrogenic properties in both ER.alpha.+ and ER.beta.+ cells. These estrogenic effects include estrogen response element (ERE) stimulation as well as tumor necrosis factor (TNF) repression. Methods are provided for treating climacteric symptoms, breast and/or uterine cancer, and osteoporosis.