The invention relates to novel chemical compounds, compositions and
methods of making and using the same. In particular, the invention
provides pyridazine compounds and/or related heterocyclic derivatives,
compositions comprising the same, and methods of using pyridazine
compounds and/or related heterocyclic derivatives and compositions
comprising the same, for modulation of cellular pathways (e.g., signal
transduction pathways), for treatment or prevention of inflammatory
diseases (e.g., Alzheimer's disease), for research, drug screening, and
therapeutic applications.