A biodegradable antithrombotic conjugate having heparin and other
anti-thrombotic moieties are introduced as side chains to the polymer
backbone modified by click chemistry. Various bioabsorbable monomers and
dimers such as valerolactone may be used in the monomer derivation, homo-
and co-polymerization, and the conjugation with a biologically active
molecule by click chemistry. A coating comprising a biocompatible and
bioabsorbable polymer anti-thrombotic conjugate is applied to at least a
portion of an implantable device to prevent or reduce the formation of
thrombosis on the surface of the implantable device. A first or sub-layer
of the coating is prepared by mixing a polymeric material and a
biologically active agent with a solvent, thereby forming a homogeneous
solution. A second or outer layer comprising the present anti-thrombotic
conjugate may be applied over the inner drug-containing layers using, for
example, a dip coating or spray coating process.