A system and method in which image processing parameters that are used globally or which change locally within the image are adapted to improve image quality by using the acquisition parameters, image analysis data, and calibration/model data. Image processing parameters are established as a function of the acquisition parameters. The acquisition parameters include one or more of an x-ray tube voltage, a pre-filtration, a focal spot size, an x-ray source to detector distance (SID), and a detector readout mode. Image processing parameters may also be established as a function of local or global image analysis, such as signal-to-noise ratio, as well as a function of predicted signal-to-noise ratio determined from the calibration data and a predetermined model.