This invention provides prokaryotic .beta.1,4-N-acetylgalactosaminyl (GalNAc) transferases involved in synthesis of lipooligosaccharide (LOS). .beta.1,4-GalNAc transferases are obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the .beta.1,4-GalNAc transferases, as well as expression vectors and host cells for expressing the .beta.1,4-GalNAc transferases.

 
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