The invention provides novel compositions, methods and uses, for the
prediction, diagnosis, prognosis, prevention and treatment of malignant
neoplasia and cancer. The invention further relates to genes that are
differentially expressed in tissue of cancer patients versus those of
normal "healthy" tissue. Differentially expressed genes for the
identification of patients which are likely to respond to chemotherapy
are also provided. The present invention relates to methods for prognosis
the prediction of therapeutic success in cancer therapy. In a preferred
embodiment of the invention it relates to methods for prediction of
therapeutic success of combinations of signal transduction inhibitors,
therapeutic antibodies, radio- and chemotherapy. The methods of the
invention are based on determination of expression levels of 48 human
genes which are differentially expressed prior to the onset of
anti-cancer chemotherapy. The methods and compositions of the invention
are most useful in the investigation of advanced colorectal cancer, but
are useful in the investigation of other types of cancer and therapies as
well.