Leukocyte Function-Associated Antigen One (LFA-1) is a cell adhesion
molecule selectively expressed on leukocytes, and plays a major role in
the activation and trafficking of T lymphocytes in the tissue at sites of
inflammation. In the last decade a large body of preclinical data has
accumulated to establish the importance of LFA-1 as a biological target,
10 particularly in chronic, T-cell driven inflammatory conditions. The
present invention provides pharmaceutically active 1,4-diazepan-2-ones of
formula I useful for the treatment of conditions related to LFA-1
activity.