A smooth portion is efficiently extracted from an image. There is provided an entropy filter in which a noted pixel (x, y) is determined in an original image, said image is partitioned by a window of size (width, height)=(A, B) from the noted pixel, entropy of the partitioned window is calculated, and obtained entropy value is saved on the coordinates (x, y) of a resulting image. Here, in a noted pixel (x, y), x is ranged from 0 to (an image width minus a window width) and y is ranged from 0 to (an image height minus a window height). By using an entropy filter, a smooth portion in image quality is extracted from an original image. A preferred example of the smooth portion is a cell nucleus.

 
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