This invention provides methods of using various herbal compositions to treat neurodegenerative diseases and neuronal dysfunctions, said compositions comprise a combination of Radix angelica sinensis (DangGui), Ligusticum chuanxiong (ChuanXiong), Hirudo (ShuiZhi), Polygonatum sibiricum (HuangJing), Carthamus tinctorius (Hong Hua), Astragalus membranaceus (HuangQi), and Glycyrrhiza uralensis (Gancao).