Disclosed are thrombin peptide derivative dimers comprising two
polypeptides having the amino acid sequence
Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val (SEQ ID NO:2), or
a C-terminal truncated fragment of the polypeptide having at least six
amino acids. Zero, one, two, or three amino acids in the polypeptide or
polypeptide fragment differ from the corresponding position of SEQ ID
NO:2. Also disclosed are methods of treating a subject in need of
treatment with a thrombin receptor agonist. The methods comprise the step
of administering an effective amount of the thrombin peptide derivative
described above.