A unified and flexible signaling method and radio interface accommodate different multiple access schemes, e.g, FDMA, TDMA, CDMA, OFCDM, and IFDMA. Each user data unit is associated with one of several different multiple access techniques that defines how multiple users access communication resources. Each user data unit is processed into discrete samples, where the discrete samples for each user data unit are assigned to one or more respective discrete signal blocks. Discrete samples associated with different multiple access techniques are processed and grouped together into a time slot or packet for transmission over a communication channel.