The invention relates to an immunogenic complex comprising at a least one
glycoside and at least one lipid, integrated into an iscom complex or
matrix, and at least one antigen which antigen is integrated into the
iscom complex or coupled on to or mixed with the iscom complex or iscom
matrix complex, characterised in that it also comprises at least one
enzyme. It also relates to such a complex further comprising at least one
peptide which specifically binds to a receptor expressed on a cell
capable of antigen presentation, which cell expresses MHC Class I or
Class II and to compositions comprising the complexes.