Device and method for needle penetrating and filling a chamber with a
predetermined substance, and laser resealing a resulting needle hole in
the device. A needle penetrable and laser resealable portion is
pierceable with a needle to form a needle aperture therethrough to fill
the chamber, and is laser resealable to hermetically seal the needle
aperture by applying laser radiation. The needle penetrable and laser
resealable portion defines a predetermined wall thickness in an axial
direction thereof, and includes a thermoplastic that substantially
prevents the formation of particles released into the chamber during
penetration by and withdrawal of the needle. The thermoplastic includes a
predetermined amount of pigment that allows it to substantially absorb
laser radiation at the predetermined wavelength, substantially prevent
the passage of radiation through the predetermined wall thickness
thereof, and hermetically seal a needle aperture formed in the needle
penetration region thereof in a predetermined time period.