Ultrasound systems and methods are described to measure changes in cardiac chamber volumes and organ wall areas, thicknesses, volumes and masses between the cardiac chambers using computer readable media employing image processing algorithms applied to 3D data sets acquired at systole and diastole. The systems for cardiac imaging includes an ultrasound transceiver configured to sense the mitral valve of a heart by Doppler ultrasound, an electrocardiograph connected with a patient and synchronized with the transceiver to acquire ultrasound-based 3D data sets during systole and diastole at a transceiver location determined by Doppler ultrasound affected by the mitral valve, and a computer readable medium configurable to process ultrasound imaging information from the 3D data sets communicated from the transceiver.