A compound represented by the following general formula (I) or a salt thereof, or a hydrate thereof or a solvate thereof having an inhibitory action against plasminogen activator inhibitor-1 (PAI-1): wherein R.sup.1 represents a C.sub.6-10 aryl group; or a substituted C.sub.6-10 aryl group, R.sup.2 represents a C.sub.6-10 aryl group; or a C.sub.6-10 aryl group substituted with a group or groups selected from the group consisting of a halogen atom, nitro group, a C.sub.1-6 alkyl group, a halogenated C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a halogenated C.sub.1-6 alkoxy group, a phenyl group and carboxy group, X represents --CH.sub.2--, --CH.sub.2CH.sub.2--, --CH.dbd.CH-- or --N(R.sup.3)--C(.dbd.O)--, Y represents carboxy group or a bioisostere of carboxy group, R.sup.3 represents hydrogen atom, a C.sub.1-4 alkyl group or a C.sub.7-12 aralkyl group, m represents 0 or 1.

 
Web www.patentalert.com

< Inhibitors of Ccr9 Activity

> Treatment and Prevention of Liver Disease Associated with Parenteral Nutrition (PN)

~ 00473