A tooth mold retaining frame comprises an L shape seat; a pivotal block; a universal connector; a first positioning block; a second positioning block; and a first fine adjust unit. By using the first fine adjust unit, second fine adjust unit and the fine-adjust device, an upper teeth mold, and a lower teeth mold can move with respect to one another precisely. By a universal connector, the upper teeth mold can move three directionally and can lift or descend proportionally so as to avoid the error in manufacturing of the teeth mold. Thus the teeth mold can be made precisely and the condition of the teeth mold can be viewed conveniently. Furthermore, the teeth mold can be sent directly without needing to send the teeth frame. Thus, the manufacturer can make the teeth mold continuously without affecting the working time.