Compounds having activity as inhibitors of IKK are disclosed, particularly IKK-2. The compounds of this invention are anilinopyrimidine derivatives having the following structure: ##STR00001## wherein R.sub.1 and R.sub.6 are as defined herein. Such compounds have utility in the treatment of a wide range of conditions that are responsive to IKK inhibition. Thus, methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.

 
Web www.patentalert.com

< Peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use

> Piperidine derivatives useful as CCR5 antagonists

~ 00472