Staggered interleaved Nyquist regions associated with differing ADC clock rates (F.sub.CLK) avoids spectrum lost through disjoint guard bands at the end of or between adjacent Nyquist regions. The staggered interleaved Nyquist regions overlap by an amount at least as much as is consumed by the guard bands. Selectable anti-aliasing filters associated with each Nyquist region and its ADC clock rate are used to enforce the staggered Nyquist regions and their various guard bands. For example, and neglecting guard bands, an initial raw band of operation RB.sub.1 may be the First Nyquist region for a basic sampling frequency F.sub.s. An adjacent raw band of operation RB.sub.2 that overlaps RB.sub.1 may be the Second Nyquist region for an alternate sampling frequency 2F.sub.s/3. An adjacent raw band of operation RB.sub.3 that overlaps RB.sub.2 may be the Second Nyquist region for the basic sampling frequency F.sub.s. These raw bands interleave and overlap: TABLE-US-00001 RB.sub.1: DC to F.sub.s/2 1.sup.st Nyq. for F.sub.CLK = F.sub.s RB.sub.2: (2/3)F.sub.s - to 2(2F.sub.s/3)/2 = 2.sup.nd Nyq. for F.sub.CLK = 2F.sub.s/3 (1/2)(2/3F.sub.s) = F.sub.s/3 2F.sub.s/3 RB.sub.3: F.sub.s - (1/2)F.sub.s = F.sub.s/2 to 2(F.sub.s/2) = F.sub.s 2.sup.nd Nyq. for F.sub.CLK = F.sub.s In this example the smallest overlap is F.sub.s/6. We then select widths for guard bands that do not exceed F.sub.s/6. Additional ADC clock rates and anti-aliasing filters may be used to operate in still higher Nyquist regions.