In a motor vehicle, when an intake air temperature Ta is not lower than a preset reference temperature Tref, warm-up drive control selectively uses an evaporated fuel processing acceleration operation curve, which gives a high level of a negative pressure in an intake manifold, to set a target drive point of an engine and controls the operation of the engine. This ensures good emission of the engine. When the intake air temperature Ta is lower than the preset reference temperature Tref and when the setting of a heating demand Hq requires heating, on the other hand, the warm-up drive control increases an EGR quantity from an ordinary level and switches over an operation mode of a cooling system for the engine to a warm-up circulation mode for making the flow of a cooling medium bypass a radiator.

 
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> Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents

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