This invention relates to Activity Dependent Neurotrophic Factor I complex
(ADNF I complex) and polypeptides of this complex, which produce their
neurotrophic effects through multiple proteases intrinsic to the ADNF I
complex. The invention also relates to pharmaceutical compositions
comprising ADNF I complex polypeptides, as well as methods for reducing
neuronal cell death in vitro and in vivo, methods for treating oxidative
stress in a patient, methods for reducing a condition associated with
fetal alcohol syndrome in a subject, and methods of enhancing learning
and memory both pre- and post-natally, all of which methods use the ADNF
I complex polypeptides of the invention.