This invention relates to hydroxy-tetrahydro-naphthalenylurea derivatives
and salts thereof which are useful as active ingredients of
pharmaceutical preparations. The hydroxy-tetrahydro-naphthalenylurea
derivatives of the present invention have an excellent activity as VR1
antagonist and are useful for the prophylaxis and treatment of diseases
associated with VR1 activity, in particular for the treatment of urinary
incontinence, urge urinary incontinence, overactive bladder, chronic
pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain,
neuralgia, neuropathies, algesia, nerve injury, ischaemia,
neurodegeneration, stroke, inflammatory disorders, asthma and COPD.