A therapeutic formulation in the form of a beadlet, suitable for oral
administration and adapted to provide immediate and sustained release of
therapeutic material. Each beadlet comprises an extruded-spheronized
inner core containing at least one medicament e.g. a slow release
vitamin, an outer layer containing at least one medicament e.g. a fast
release vitamin and a controlled release coating between the inner core
and the outer layer which coating controls the release of the inner core
medicament.