In the method, a reference core design is generated based on a defined set of limits. The set of limits may include a target hot excess reactivity constraint to be satisfied over a given core energy cycle and a given desired control blade definition that is set for the cycle. A reference core design is generated based on the defined limits. A unique subset of fresh fuel bundles is subject to an iterative improvement process including replacing, at each fuel location, at least one of the current fresh fuel bundles with at least one of the selected fresh fuel bundles, and simulating reactor operation on the reference core design to obtain a plurality of outputs to be ranked based on the defined set of limits. The highest ranked output may represent an accepted core design with set control blade definition that satisfies the target hot excess reactivity constraint.