An optical pickup guiding structure for an optical disk drive is provided. The optical pickup guiding structure comprises a pickup base with a pickup window formed therein, and an optical pickup that is provided in the pickup window and that includes at least one end movably supported by a molded structure integrally formed on the pickup base. The end of the optical pickup and a molded structure for movably supporting the end of the optical pickup are formed with a guide channel and a guide rib, respectively, which are complementary to each other, thereby guiding the optical pickup. Because the number of parts of the optical disk chive is minimized, and the change in the installation state of the optical pickup is minimized during use, the operational reliability is improved.