Systems and methods for multiframe alignment in a multipoint-to-point orthogonal frequency division multiplexing (OFDM system are provided. In one embodiment, an (OFDM) communication system comprises: a host unit; a plurality of remote units that access the host unit using an orthogonal frequency division multiple access scheme; wherein each of the remote units modulates upstream information into an OFDM signal modulated using a Fourier transform; wherein the host unit receives upstream OFDM signals from a plurality of the remote units, wherein portions of the upstream OFDM signals arrive at the host unit at the same time; and wherein the host unit causes at least one remote unit to align symbols with symbols transmitted from another remote unit based on a predefined multiframe pattern.