The cell observation device and method aims to easily study the
correlation between initial states of cells and their reactions without
using a synchronous culture method. For this purpose, the cell
observation device includes an image acquisition unit acquiring an image
of a specimen including a plurality of cells; a stimulating unit applying
a predetermined stimulation to the plural cells; a determining unit
determining initial states of the plural cells from the image which is
acquired by the image acquisition unit before the stimulating unit
applies the stimulation; a finding unit finding reactions of the plural
cells to the stimulation, from the image acquired by the image
acquisition unit after the stimulating unit applies the stimulation; and
a generating unit generating information on correlation between the
initial states and the reactions of the plural cells.