The present invention relates generally to a computer model of an adaptive
immune response. One embodiment of the invention relates to a computer
model of an adaptive immune response within the framework of signals
conveyed at the site of antigen exposure. Another embodiment of the model
includes a representation of complex physiological regulatory mechanisms
related to, for example, cellular dynamics, mediator production,
antigen-presenting cell (APC) recruitment, APC maturation, lymphocyte
activation, lymphocyte trafficking, and/or lymphocyte effector function.
In another embodiment, the model can account for mediator production in
response to antigen within a chronically inflamed peripheral tissue, as
well as the regulatory effects of mediators on APC and lymphocyte
population dynamics, including maturation, activation, and apoptosis, and
the regulatory effects of mediators produced by APCs and lymphocytes on a
chronically inflamed peripheral tissue. Another embodiment of the
invention relates to an analytical model of an adaptive immune response.