Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease.

 
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< Crystals of unliganded beta secretase and/or beta secretase-like proteins and the use thereof

> Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of .beta.-secretase
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