A wireless communication system, and method using multiple antennas, includes a base station that applies predetermined weight vectors to multi-user signals and transmits the multi-user signals through a plurality of transmission antennas, and a plurality of mobile stations that receive and process the multi-user signals, wherein each mobile station includes a signal reception unit that processes the multi-user signals, and a feedback signal generation unit that estimates channel characteristics, over which the multi-user signals have been transmitted, from the multi-user signals, classifies a plurality of weight vectors to be applied to the estimated channel characteristics into a plurality of sets such that vectors orthogonal to one another are classified into a single set, selects a set maximizing a transmission capacity from among the classified sets, and feeds back weight indexes of weight vectors included in the selected set and weighted channel information to the base station.