A signal processing system allows reconstruction of a non-uniformly sampled analog signal including sampling an analog signal at a sampling period of resulting in a quantized non-uniformly sampled signal. The non-uniformly sampled signal includes a sampled signal and an amplitude error between a signal sampled with the equidistant sample period and the non-uniformly sampled signal. A reconstructed amplitude error is determined through the time offset and the non-uniformly sampled signal, and is subtracted from the non-uniformly sampled signal. The signal processing system may be implemented in an electrocardiogram monitoring device or a mobile phone device.