Systems, methods and a software product for disease reduction education and risk assessment are disclosed. In one embodiment, a system for computer-assisted disease risk assessment and education includes a processor that generates at least a plurality of questions directed to a disease risk assessment for a user. Based upon responses received from a user, the processor is further operable to generate one or more plans configured to prospectively guide the risk behavior and sexual activity of the user. At least one personal data entry and display device (PDDA) is communicatively coupled to the processor, that is operable to at least display the plurality of questions and to accept corresponding responses from the user.