An article of manufacture is provided comprising a vial having (a) a first
chamber that is substantially filled with an injectable pharmaceutical
formulation; (b) a second chamber that is substantially empty but for a
gaseous medium; (c) a septum, impermeable to the gaseous medium,
separating the first and second chambers; and (d) actuating means
effective to bring the formulation and the gaseous medium into contact by
breach of the septum such that the gaseous medium acts as an effective
headspace for agitation of the formulation. The formulation comprises an
aqueous medium, a drug in solid particulate form in a therapeutically
effective amount suspended in the medium, and one or more wetting and/or
suspending agents in an amount effective to provide controlled
flocculation of the drug, at least one ingredient of the formulation
being susceptible to oxidative degradation.