The invention features methods and compositions for assessing risk,
particularly immediate risk, of thrombotic events in patients with
suspected or known vascular disease, and more particularly to assessing
risk of thrombotic events in patients with coronary artery disease,
particularly acute myocardial infarction, stroke, unstable angina, stable
angina, or restenosis. Risk of thrombosis can be assessed by analysis of
platelet reactivity and/or velocity of thrombin or fibrin formation, and
determining whether the patient has a score associated above a risk
threshold value. In other embodiments, risk of thrombosis in a patient is
evaluated in the context of a profile generated from values obtained from
one or more assays that evaluate various factors associated with
thrombosis and/or atherosclerosis.