A lipolysis system configured for contacting and providing low-power laser irradiation to a plurality of targeted portions of a subject's body surface for the purpose of liquefying fats in subcutaneous regions underlying the targeted body surface portions, and methods for the use of the lipolysis system. The lipolysis system comprises: (a) a first laser applicator comprising a plurality of low-power laser diodes selected for emission of power outputs in the range comprising about 10 mW to about 100 mW with light waves in the range of 635 nm to 680 nm, (b) a second laser applicator comprising at least one low-power laser diode selected for emission of power outputs in the range comprising about 10 mW to about 100 mW with light waves in the range of 635 nm to 680 nm, and (c)a laser control device configured for controllably communicating and cooperating with said first laser applicator and said second laser applicator.