The present invention discloses compositions, comprising a lipid-polymer
matrix to mask the bitter or unpleasant taste of the medicament. The
lipid or a blend of lipids, are used in combination with the pH dependent
polymer where the said polymer is acid soluble or swellable The process
for the preparation of taste masked pharmaceutical compositions of the
bitter drugs comprising the said lipid-polymer compositions are
disclosed. The concomitant use of the acid soluble polymer, which remains
collapsed at the pH of saliva, inhibits the release of drug at that pH
and hence they further help in bitterness inhibition. The said
compositions deliver substantial amount of the bitter drug immediately at
the gastric pH with improved palatability.