A novel human sodium phosphate cotransporter expressed on the apical
surface of intestinal epithelial cells (huNpt2B) and polypeptides related
thereto, as well as nucleic acid compositions encoding the same, are
provided. The subject polypeptides and nucleic acid compositions find use
in a variety of applications, including research, diagnostic, and
therapeutic agent screening applications. Also provided are methods of
inhibiting Npt2B activity in a host and methods of treating disease
conditions associated with Npt2B activity.