The present invention concerns piperidine-amino-benzimidazoles having
inhibitory activity on the replication of the respiratory syncytial virus
and having the formula ##STR00001## their prodrugs, N-oxides, addition
salts, quaternary amines, metal complexes and stereochemically isomeric
forms wherein Q is C.sub.1-6alkyl optionally substituted with
trifluoromethyl, C.sub.3-7cycloalkyl, Ar.sup.2, hydroxy, C.sub.1-4alkoxy,
C.sub.1-4alkylthio, Ar.sup.2-oxy-, Ar.sup.2-thio-,
Ar.sup.2(CH.sub.2).sub.noxy, Ar.sup.2(CH.sub.2).sub.nthio,
hydroxycarbonyl, aminocarbonyl, C.sub.1-4alkyl-carbonyl,
Ar.sup.2carbonyl, C.sub.1-4alkoxycarbonyl,
Ar.sup.2(CH.sub.2).sub.ncarbonyl, aminocarbonyloxy,
C.sub.1-4alkylcarbonyloxy, Ar.sup.2carbonyloxy,
Ar.sup.2(CH.sub.2).sub.ncarbonyloxy,
C.sub.1-4alkoxy-carbonyl(CH.sub.2).sub.noxy, mono- or
di(C.sub.1-4alkyl)aminocarbonyl, mono- or
di(C.sub.1-4alkyl)-aminocarbonyloxy, aminosulfonyl, mono- or
di(C.sub.1-4alkyl)aminosulfonyl or a heterocycles selected from the group
consisting of pyrrolidinyl, pyrrolyl, dihydropyrrolyl, imidazolyl,
triazolyl, piperidinyl, homopiperidinyl, piperazinyl, morpholinyl,
thiomorpholinyl, 1-oxo-thiomorpholinyl, 1,1-dioxothiomorpholinyl, pyridyl
and tetrahydropyridyl, wherein each of said heterocycle may optionally be
substituted with oxo or C.sub.1-6alkyl; G is a direct bond or optionally
substituted C.sub.1-10alkanediyl; R.sup.1 is Ar.sup.1 or a monocyclic or
bicyclic heterocycle; one of R.sup.2a and R.sup.3a is C.sub.1-6alkyl and
the other one of R.sup.2a and R.sup.3a is hydrogen; in case R.sup.2a is
different from hydrogen then R.sup.2b is hydrogen or C.sub.1-6alkyl, and
R.sup.3b is hydrogen; in case R.sup.3a is different from hydrogen then
R.sup.3b is hydrogen or C.sub.1-6alkyl, and R.sup.2b is hydrogen; t is 1,
2 or 3; Ar.sup.1 is phenyl or substituted phenyl; and Ar.sup.2 is phenyl
or substituted phenyl. It further concerns their preparation and
compositions comprising them, as well as their use as a medicine.