The present disclosure provides a nutraceutical for the use of a vacuolar flavonoid pigment from a natural source such as tart cherries as an additional compound as part of a mixture including at least an amino sugar, such as glucosamine, and a sulfated glycosaminoglycan, such as chondroitin sulfate. What is also contemplated is the use of the vacuolar flavonoid pigment in conjunction with other known joint regeneration nutraceuticals, including a mixture of glucosamine, chondroitin sulfate, and MSM, and a method of treatment of osteoarthritis.