The present invention provides a number of gene markers whose expression
is altered in various gliomas. In particular, by examining the expression
these markers, one can accurately classify a glioma as glioblastoma
multiforme (GM), anaplastic astrocytoma (AA), anaplastic
oligodendroglioma (AO) or oligodendroglioma (OL). The diagnosis may be
performed on nucleic acids, for example, using a DNA microarray, or on
protein, for example, using immunologic means. Also disclosed are methods
of therapy.