Medical imaging and navigation system including a processor, a medical positioning system (MPS), a two-dimensional imaging system and an inspected organ monitor interface, the MPS including an imaging MPS sensor, the two-dimensional imaging system including an image detector, the processor being coupled to a display unit and to a database, the MPS being coupled to the processor, the imaging MPS sensor being firmly attached to the image detector, the two-dimensional imaging system being coupled to the processor, the image detector being firmly attached to an imaging catheter.