Hybrid compounds comprising a first domain and a second domain are
provided. The first domain and the second domain are preferably
covalently linked, and the first domain comprises a domain which is
capable of specific binding to Gb.sub.3; and the second domain comprising
a moiety selected from the group consisting of drug moiety, a nucleic
acid, a probe, a polypeptide, and a hook, with the proviso that the
second domain is not a verotoxin or a fragment thereof. Methods of
preparing and using the hybrid compounds are also provided.