Compounds of the following structure are described:
wherein R.sub.1-R.sub.6, R.sub.11, R.sub.12, m, V, X, Y, Z and Q are
described herein, or a pharmaceutically acceptable salt, tautomer,
metabolite or prodrug thereof. These compounds are useful for treating a
variety of hormone-related conditions including contraception, treating
or preventing fibroids, endometriosis, dysfunctional bleeding, uterine
leiomyomata, polycystic ovary syndrome, or hormone-dependent carcinomas,
providing hormone replacement therapy, stimulating food intake or
synchronizing estrus.