This invention generally relates to improvement of the body and skin
appearance, for example enhancing the appearance of sagging, wrinkled, or
cellulite-afflicted areas of the skin and body, through the local
delivery of a nitric oxide donor, for example, using delivery vehicles
such as lotions, creams, liquids, and/or transdermal patches. In some
embodiments, a delivery vehicle containing a nitric oxide donor, for
example, L-arginine (an important biological precursor) or its
derivatives in a sufficient concentration to improve the appearance of a
selected area of the body may be applied. In certain cases, one or more
agents may also be included that aid in the transfer of the nitric oxide
donor into the tissue, which may overcome the resistance to transfer into
the skin. Non-limiting examples of suitable agents include agents able to
create hostile biophysical environments, for instance, choline chloride,
magnesium chloride, and/or sodium chloride.