The use of a citrus fruit skin extract for promoting angiogenesis, or treating a disease or disorder where it is desirable to promote angiogenesis. Such diseases include coronary heart disease, stroke, or ulcers. A composition comprising an extract of citrus fruit skin suitable for use in promoting angiogenesis, or treating a disease or disorder where it is desirable to promote angiogenesis. A process for preparing a citrus fruit skin extract. The citrus fruit may be grapefruit, orange, lemon, lime, mandarin, tangelo, tangerine or uglis, preferably grapefruit (Citrus paradisii).