Methods and devices provide delivery of one or more therapeutic agents to
a treatment site at or near an aneurysm, such as an abdominal aortic
aneurysm ("AAA"). Methods typically include placing a device at or near
the AAA and releasing one or more therapeutic agents from the device.
This may also involve releasing multiple agents in sequential fashion.
Examples of possible therapeutic agents include doxycycline,
roxithromycin, tetracycline, tetracycline derivatives, and collagen
promoting agents, such as propranolol. Devices used to deliver one or
more therapeutic agents may include stents, grafts, stent grafts,
balloons with perforations and/or needles, expandable wire baskets,
drug-eluting capsules, or suitable combinations thereof. One embodiment
includes a stent graft with a distally-extending skirt and an supra-renal
anchor.