A method for the selective determination of the scattering index
.mu..sub.s of a scattering biological matrix, in particular for the
purpose of non-invasive determination of the concentration of glucose in
the skin, by means of detection measurements, in each of which light in
the form of primary light (9) is irradiated into the biological matrix
(5) and an intensity measurement value of secondary light (12) exiting at
a detection site (33-40) that is located at different measuring distances
(.rho.) from the respective light irradiation site (10) during the
detection measurements is measured. In order to improve the quality and
selectivity of the determination of .mu..sub.s, the primary light is
irradiated obliquely at an angle between 5.degree. and 85.degree. using a
contacting light-guiding element. In at least two detection measurements,
the measuring distance (.rho.) between the respective light irradiation
site (10) and the respective detection site (33-40) corresponds to no
more than five times the mean free path length of the light propagating
in the biological matrix.