A structure with embedded opto-electric components includes a carrier; at least one circuit board having a cavity and mounted on a carrier; at least one waveguide embedded in an inner layer of the circuit board and mounted on the carrier; at least one first opto-electric component embedded in the inner layer of the circuit board, and having an active terminal in contact with a transmission terminal of the waveguide; and at least one second opto-electric component mounted on the circuit board, and having an active terminal corresponding in position to another transmission terminal of the waveguide via the cavity. Since the first opto-electric component and the waveguide are in contact with each other and embedded in the circuit board, an optical transmission mechanism is simplified and times of reflection are decreased, thereby reducing errors and loss during transmission.